Real name: Unknown
A.K.A.: Dolores Winters
First Appearance: Action Comics I#13 (June 1939)
Abilities: Super scientist
Quotes: "I prefer to use this great intellect for crime. My goal-world domination!"
Worst Act: Murder, espionage, and generally trying to take over the world
Created by: Jerry Sigel (writer) and Joe Shuster/Paul Cassidy(inks/pencils
Now here's a first. The first villain Superman ever fought more than once.
Granted, the one most modern readers may been only familiar with the giant albino ape version, but the first bald mad scientist who tried to kill Superman was the Ultra-Humanite (and not Lex Luthor). When we first see him, he's a shriveled old man in a wheelchair who basically running Uber.
Superman tackles the man's plane, but no body is ever found. He would appear again and again, this time with the added gimmick of being able to have his brain transplanted into new bodies. Hollywood actress Dolores Winters is his first victim. He wouldn't become an ape until the 70's, but by that point he had become more of a footnote than a major player, often fighting against Superman of Earth-2.
Overall interesting, and an idea (sadly more or less ignored) of someone wanting Superman's body so they could put their brain in it is a unique foe.